top of page


Papa, A., Del Rivero Morfin, P.J., Chen, BX., Yang, L., Katchman, AN., Zakharov, S.I., Liu, G., Bohnen M.S., Zheng, V., Katz, M., Subramanaim, S., Hirsch, JA., Weiss, S., Dascal, N., Karlin, A., Pitt, GS., Colecraft, HM., Ben-Johny, M., and S.O. Marx. (2024). “A membrane-associated phosphoswitch in Rad controls adrenergic regulation of cardiac calcium channels." J Clin Invest. 134: e176943. PubMed


Sasson, Y., Subramanaim, S., Buki, T., Almagor, L., Chomsky-Hecht, O., Katz, M., Puhl, H. L. III, Ikeda, S. R., Dascal, N., and J. A. Hirsch. (2022). “Mapping molecular determinants of CaV2.2 inhibition by RGK proteins and homologs in Xenopus oocytes.” bioRxiv


Katz, M., Subramanaim, S., Chomsky-Hecht, O., Tsemakhovich, V, Belkacemi, A., Flockerzi, V., Klussmann, E., Hirsch, J. A., Weiss, S., and N. Dascal. (2021). “Reconstitution of β-adrenergic regulation of CaV1.2: Rad-dependent and Rad-independent protein kinase A mechanisms.” PNAS, 118: e2100021118. PubMed


Lipinsky, M., Tobelaim, W.S., Peretz, A., Simhaev, L., Yehezkel, A., Yakubovich, D., Lebel, G., Paas, Y., Hirsch, J. A., and B. Attali. (2020). “A unique mechanism of inactivation gating of the Kv channel family member Kv7.1 and its modulation by PIP2 and calmodulin.” Science Advances, 6: eabd6922. PubMed


Gomez-Llorente, Y., Jebara, F., Patra, M., Malik, R., Nisemblat, S., Chomsky-Hecht, O., Parnas, A., Azem, A.*, Hirsch, J. A.*, and I. Ubarretxena-Belandia*. (2020). “Structural basis for active single and double ring complexes in human mitochondrial Hsp60-Hsp10 chaperonin.” Nature Communications, 11: 1916. PubMed



Hazak, O., Mamon, E., Lavy, M., Sternberg, H., Behara, S., Schmitz-Thom, I., Bloch, D., et al, Mockaitis, K., Estelle, M., Hirsch, J. A., Kudla, J., and S. Yalovsky. (2019) “A novel Ca2+-binding protein that can rapidly transduce auxin responses during root growth.” PLoS Biology, 17: e3000085. PubMed


Huttunen, H., Hero, M., Laaperi, M., Kansakoski, J., Swan, H., Hirsch, J. A., Miettinen, P. J., and T. Raivio. (2017) “The Role of KCNQ1 Mutations and Maternal Beta Blocker Use During Pregnancy in the Growth of Children With Long QT Syndrome.” Front Endocrinol, 9:194. PubMed


Tommiska, J., Kansakoski, J., et al, Hirsch, J. A., Varjosalo, M., Jespersen, T., and T. Raivio. (2017) “Two missense mutations in KCNQ1 cause growth hormone deficiency and maternally inherited gingival fibromatosis.” Nature Communications, 8:1289. PubMed


Tobelaim, W.S., Dvir, M., Lebel, G., Cui, M., Buki, T., Peretz, A., Marom, M., Haitin, Y., Logothetis, D.E., Hirsch, J. A. and Attali, B. (2017). “Ca2+-Calmodulin and PIP2 interactions at the proximal C-terminus of Kv7 channels.” Channels, 11:686.  PubMed

J. A. Hirsch, (2017). “Initial Crystallographic Studies of Visual Arrestin: Insights and Perspectives.” In The Structural Basis of Arrestin Functions, ed. V.V. Gurevich. Springer (Switzerland). Springer Link

Wiener, R., Vishnivetskiy, S. A., Gurevich, V. V., and J. A. Hirsch, (2017). “Phosphate Sensor and Construction of Phosphorylation-Independent Arrestins.” In The Structural Basis of Arrestin Functions, ed. V. V. Gurevich. Springer (Switzerland). Springer Link

Tobelaim, W.S., Dvir, M., Lebel, G. , Cui, M., Buki, T., Peretz, A., Marom, M., Haitin, Y., Logothetis, D.E., Hirsch, J.A.,  and B. Attali. (2017). “Competition of calcified calmodulin N lobe and PIP2 to an LQT mutation site in Kv7.1 channel.” Proc Natl Acad Sci, 114: E869. PubMed


Strulovich, R., Tobelaim, W.S., Attali, B., and J. A. Hirsch. (2016). “Structural Insights into the M-channel Proximal C-Terminus/Calmodulin Complex.” Biochemistry, 55: 5353. PubMed

Benmocha Guggenheimer, A., Almagor, L., Tsemakhovich, V., Tripathy, D. R., Hirsch, J. A., and N. Dascal. (2016). "Interactions between N and C termini of α1C subunit regulate inactivation of CaV1.2 L-type Ca2+ channel." Channels, 10: 55. PubMed





Sachyani, D., Dvir, M., Strulovich, R., Ben-Tal Cohen, E., Tria, G., Tobelaim, W., Peretz, A., Pongs, O., Svergun, D., Attali, B., and J. A. Hirsch. (2014). “Structural Basis of a Kv7.1 Potassium Channel Gating Module: Studies of the Intracellular C-terminal Domain in Complex with Calmodulin.” Structure, 22: 1582.​ PubMed



Oz, S., Kapitansky, O., Ivashco-Pachima, Y., Malishkevich, A., Giladi, E., Skalka, N., Rosin-Arbesfeld, R., Mittelman, L., Segek, O., Hirsch, J. A., and Illana Gozes. (2014) “Molecules that Change our Minds: The NAP Targets of Nerve Cell Protection are the Microtubule End Binding Proteins.” Mol Psychiatry, 19: 1115. PubMed



Singer, R., Atar, S., Atias, O., Oron, E., Segal, D., Hirsch, J. A., Tuller, T., Orian, A., and D. A. Chamovitz. (2014) “Drosophila COP9 Signalosome Subunit 7 interacts with multiple genomic loci to regulate development.” Nucl Acids Res, 42: 9761. PubMed



Dvir, M., Strulovich, R., Sachyani, D., Ben-Tal Cohen, I., Haitin, Y., Dessauer, C., Pongs, O., Kass, R., Hirsch, J. A., and B. Attali. (2014) “Long QT mutations disrupt IKS regulation by PKA and PIP2 at the same KCNQ1 helix C-KCNE1 interface.” J Cell Science, 127: 3943. PubMed



Puhl, H. L. III, Lu, V. B., Won, Y., Sasson, Y., Hirsch, J. A., and S. R. Ikeda. (2014). “Ancient origins of RGK protein function: modulation of voltage-gated calcium channels preceded the protostome and deuterostome split.” PLoS One, 9: e100694. PubMed



Fogel, H., Frere, S., Segev, O., Bharill, S., Shapira, I., Gazit, N., O’Malley, T., Slomowitz, E., Berdichevsky, Y., Walsh, D. M., Isacoff, E. Y., Hirsch, J. A. and I. Slutsky. (2014) “APP homodimers transduce amyloid-β mediated increase in release probability at excitatory synapses.” Cell Reports, 7: 1560. PubMed





Giladi, M., Michaely, L., Almagor, L., Bar-On, D., Buki, T., Ashery, U., Khananshvili, D. †, and J. A. Hirsch†. (2013). “The C2B Domain Is The Primary Ca2+ Sensor In DOC2B: A Structural And Functional Analysis.” J Mol. Biol., 425: 4629. PubMed



Giladi, M., Hiller, R., Hirsch, J. A.†, and D. Khananshvili†. (2013). “Population shift underlies Ca2+-induced regulatory transitions in the sodium-calcium exchanger (NCX).”J Biol. Chem., 288: 23141. PubMed



Almagor, L., Avinery, R., Hirsch, J. A. †, and R. Beck†. (2013). “Structural flexibility of CaV1.2 and CaV2.2 I-II proximal linker fragments in solution.” Biophys J, 104: 2392. PubMed



Oz, S., Benmocha, A., Sasson, Y., Sachyani, D., Almagor, L., Lee, A., Hirsch, J. A., and N. Dascal. (2013). “Competitive and non-competitive regulation of calcium dependent inactivation in CaV1.2 L-type Ca2+ channels by calmodulin and Ca2+-binding protein 1.” J Biol. Chem., 288:12680. PubMed





Kotiguda, G. G., Weinberg, D., Dessau, M., Salvi, C., Serino, G., Chamovitz, D. A.†, and J. A. Hirsch†. (2012). “The organization of a CSN5-containing subcomplex of the COP9 signalosome.” J Biol. Chem., 287:42031. PubMed




Almagor, L., Chomsky-Hecht, O., Ben-Mocha, A., Hendin-Barak, D., Dascal, N., and J. A. Hirsch. (2012). “CaV1.2 I-II linker structure and Timothy syndrome.” Channels, 6:468. PubMed




Giladi, M., Sasson, Y., Fang, X., Hiller, R., Buki, T., Wang, Y-X., Hirsch, J. A. and D. Khananshvili. (2012). “A Common Ca2+-driven Interdomain Module Governs Eukaryotic NCX Regulation.” PLoS One, 7:e39985. PubMed




Almagor, L., Chomsky-Hecht, O., Ben-Mocha, A., Hendin-Barak, D., Dascal, N., and J. A. Hirsch. (2012). “The Role of a Voltage-dependent Ca2+ Channel Intracellular Linker: A Structure-Function Analysis.” J Neuroscience, 32:7602. PubMed






Etzioni, A., Siloni, S., Chikvashili, D., Strulovich, R., Sachyani, D., Regev, N., Greitzer-Antes, D., Hirsch, J. A., and I. Lotan. (2011)."Regulation of Neuronal M Channel Gating in an Isoform-Specific Manner: Functional Interplay between Calmodulin and Syntaxin 1A." J Neuroscience, 31:14158. PubMed




Sasson, Y., Navon-Perry, L., Huppert, D., and J. A. Hirsch. (2011). “RGK Family G-domain-GTP Analog Complex Structures and Nucleotide-binding Properties.” J Mol. Biol., 413:372. PubMed




Halimi, Y., Dessau, M., Pollack, S., Ast, T., Karniol, B., Hirsch, J. A., and D. A. Chamovitz. (2011). “COP9 Signalosome subunit 7 (CSN7) from Arabidopsis is a negative regulator of the nuclear localization of the small subunit of ribonucleotide reductase (RNR2).” Plant Mol Biol., 77: 77. PubMed






Adi-Harel, S., Erlich, S., Schmukler, E., Cohen-Kedar, S., Segev, O., Mizrachy, L., Hirsch J. A., and R. Pinkas-Kramarski. (2010). "Beclin 1 self-association is independent of autophagy induction by amino acid deprivation and rapamycin treatment." J Cell Biochem., 110:1262. PubMed




Sorek, N., Segev, O., Gutman, O., Bar, E., Richter, S., Poraty, L., Hirsch, J. A., Henis, Y.I., Lewinsohn, E., Jürgens, G., and S. Yalovsky. (2010) "An S-acylation switch of conserved G domain cysteines is required for polarity signaling by ROP GTPases." Current Biol., 20:914. PubMed




Benmocha, A., Almagor, L., Oz, S., Hirsch, J.A., and N. Dascal. (2009). “Characterization of the calmodulin-binding site in the N terminus of CaV1.2.” Channels, 3: 337. PubMed



Haitin, Y., Wiener, R., Shaham, D., Peretz, A., Cohen, E.B., Shamgar, L., Pongs, O., Hirsch, J.A., and B. Attali. (2009). “Intra-cellular domains interactions and gated motions of IKS potassium channel subunits.” EMBO J, 28: 1994. PubMed




Dessau, M., Halimi, Y., Erez, T., Chomsky-Hecht, O., Chamovitz, D.A., and J. A. Hirsch. (2008). “The Arabidopsis COP9 Signalosome Subunit 7 Is a Model PCI Domain Protein with Subdomains Involved in COP9 Signalosome Assembly.” The Plant Cell, 20: 2815. PubMed




Wiener, R., Haitin, Y., Shamgar, L., Fernandez-Alonso, M.C., Martos, A., Chomsky-Hecht, O., Rivas, G., Attali, B., and J.A. Hirsch. (2008) “The KCNQ1(Kv7.1) COOH-terminus, a Multitiered Scaffold for Subunit Assembly and Protein Interaction.” J Biol. Chem, 283:5815. PubMed



Ehrlich, S., Mizrachy, L., Segev, O., Lindenboim, L., Zmira, O., Adi-Harel, S., Hirsch, J. A., Stein, R., and R. Pinkas-Kramarski. (2007). “Differential Interactions Between Beclin 1 and Bcl-2 Family Members.”Autophagy, 3: 561. PubMed



Dessau, M., Chamovitz, D.A., and J. A. Hirsch. (2006). “Expression, Purification and Crystallization of a PCI domain from the COP9 signalosome subunit 7 (CSN7).” Acta Cryst. F, 62: 1138. PubMed



Opatowsky, Y., Sasson, Y., Shaked, I., Ward, Y., Chomsky-Hecht, O., Litvak, Y., Selinger, Z., Kelly, K. ., and J. A. Hirsch. (2006). “Structure-function studies of the G-domain from human gem, a novel small G-protein.”FEBS Letters, 580: 5959. PubMed



Shamgar, L., Ma, L., Schmitt, N., Haitin, Y., Peretz, A., Wiener, R., Hirsch, J., Pongs, O., and B. Attali. (2006). Calmodulin is essential for cardiac IKS channel gating and assembly: impaired function in long-QT mutations. Circulation Research. 98:1055. PubMed



Opatowsky, Y., Chen, C-C., Campbell, K. P., and J. A. Hirsch. (2004). “Structural Analysis of the Voltage-Dependent Calcium Channel Beta Subunit Functional Core and Its Complex with the Alpha1 Interaction Domain.” Neuron, 42: 387. PubMed



Opatowsky, Y., Chomsky-Hecht, O., and J. A. Hirsch. (2004). “ Expression, Purification and Crystallization of a Functional Core of the Voltage-Dependent Calcium Channel Beta Subunit.” Acta Cryst. D, 60: 1301. PubMed




Opatowsky, Y., Chomsky-Hecht, O., Kang, M-G., Campbell, K. P., and J. A. Hirsch. (2003). “The Voltage-Dependent Calcium Channel Beta Subunit Contains Two Stable Interacting Domains.” J Biol. Chem., 278: 52323. PubMed




Zoref-Shani, E., Bromberg, Y., Hirsch, J., Feinstein, S., Frishberg, Y., and O. Sperling. (2003). “A Novel Point Mutation (I136T) in the Conserved 5-Phosphoribosyl-1-Pyrophosphate Binding Motif of Hypoxanthine-guanine Phosphoribosyltransferase (HPRTJerusalem ) in a Patient with Kelley-Seegmiller Syndrome.”Mol. Genetics and Metabolism, 78:158. PubMed



Vishnivetskiy, S. A., Hirsch J. A., Velez, M. G., Gurevich, Y. V., Gurevich, V. V. (2002). “Arrestin's transition into the active receptor-binding state requires an extended interdomain hinge." J Biol. Chem., 277:43961. PubMed


bottom of page